Mystery Girls follows two former detective TV show starlets brought back together by a real-life mystery. Charlie Contour is a suburban housewife and mother, while Holly Hamilton longs for her glory days in the 90's when she was on television. Both of their lives are disrupted when Nick, a witness to a crime and a ‘Mystery Girls' fanatic, will only speak to the infamous duo, and the former friends must reunite and put their TV crime-solving skills to the test.