“So just sit right down, relax, open your ears real wide and say, "Give it to me straight, Doctor. I can take it!"”

When a Cincinnati radio station switches from sedate music to top-40 rock 'n' roll, its staff of oddball characters is forced to switch gears quickly. New programming director Andy Travis brings in a new DJ named Venus Flytrap to work with the station's burned-out veteran, Dr. Johnny Fever. Neurotic newsman Les Nessman, eager beaver Bailey Quarters, sleazy salesman Herb Tarlek, blonde bombshell Jennifer Marlowe, who serves as the station's ultra-capable receptionist, and station manager Arthur Carlson, whose domineering mother owns WKRP, round out the eccentric bunch.